PARP3

Description		poly(ADP-ribose) polymerase family member 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Centriole Cytoskeleton Nuclear Body Site Of Double-strand Break Intercellular Bridge
	Molecular Function	Catalytic Activity NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity NAD DNA ADP-ribosyltransferase Activity NAD+-protein-lysine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Telomere Maintenance DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Negative Regulation Of Macromolecule Biosynthetic Process DNA ADP-ribosylation Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Isotype Switching Negative Regulation Of DNA Metabolic Process Regulation Of Mitotic Spindle Organization Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Protein Localization To Site Of Double-strand Break Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
Drugs		2-methyl-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one 4-[3-(1,4-diazepan-1-ylcarbonyl)-4-fluorobenzyl]phthalazin-1(2H)-one N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE Olaparib Rucaparib
Diseases
GWAS
Novel Interacting Genes		5 novel interacting genes: APP BAP1 H1-1 MEOX2 PARP1
Interacting Genes		5 interacting genes: APP BAP1 H1-1 MEOX2 PARP1
Entrez ID		10039
HPRD ID		06370
Ensembl ID		ENSG00000041880
Uniprot IDs		Q9Y6F1
PDB IDs		2EOC 3C49 3C4H 3CE0 3FHB 4GV0 4GV2 4GV4 4L6Z 4L70 4L7L 4L7N 4L7O 4L7P 4L7R 4L7U
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Regulation Of ATP Metabolic Process NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity Chromatin Organization NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Response To Nerve Growth Factor Response To Amyloid-beta Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Amyloid-beta NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Chromatin Binding NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Cellular Response To Nerve Growth Factor Stimulus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Chromatin DNA Binding Nucleate Erythrocyte Differentiation Thrombocyte Differentiation DNA ADP-ribosylation Positive Regulation Of Myofibroblast Differentiation Chromosome Myeloid Leukocyte Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of ATP Biosynthetic Process NAD+-protein-serine ADP-ribosyltransferase Activity Negative Regulation Of DNA Metabolic Process Regulation Of Protein Localization To Nucleus Regulation Of DNA Recombination NAD DNA ADP-ribosyltransferase Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization
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