MEF2B

Description		myocyte enhancer factor 2B
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Cell Junction
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Heart Development Muscle Organ Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development
Pathways		Myogenesis
Drugs
Diseases
GWAS		Diastolic blood pressure ( 29403010 30487518) Mean arterial pressure ( 29403010 30487518) Multiple sclerosis ( 31604244) Schizophrenia ( 34099189) Schizophrenia x sex interaction ( 34099189) Systolic blood pressure ( 30487518)
Novel Interacting Genes		2 novel interacting genes: CABIN1 HDAC4
Interacting Genes		2 interacting genes: CABIN1 HDAC4
Entrez ID		100271849
HPRD ID		19467
Ensembl ID		ENSG00000213999
Uniprot IDs		Q02080
PDB IDs		1N6J 1TQE 6BYY 6BZ1 6C9L 6WC2 6WC5
Enriched GO Terms of Interacting Partners?		Response To Muscle Inactivity Response To Denervation Involved In Regulation Of Muscle Adaptation Negative Regulation Of Myotube Differentiation Histone Deacetylase Activity Macromolecule Deacylation Negative Regulation Of Transcription By Competitive Promoter Binding Potassium Ion Binding Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Protein Sumoylation Negative Regulation Of Glycolytic Process Chromatin Remodeling Cardiac Muscle Hypertrophy Protein Deacetylation SUMO Transferase Activity Muscle Hypertrophy Protein Lysine Deacetylase Activity Response To Inactivity DNA-binding Transcription Activator Activity Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of ATP Metabolic Process Chromatin Organization Positive Regulation Of Protein Sumoylation Aggresome Nucleosome Binding Negative Regulation Of Striated Muscle Cell Differentiation Histone Deacetylase Complex Protein Phosphatase Inhibitor Activity Regulation Of Myotube Differentiation Type I Interferon-mediated Signaling Pathway Regulation Of Glycolytic Process Protein Sumoylation Regulation Of Carbohydrate Catabolic Process Transcription Repressor Complex Interferon-mediated Signaling Pathway Negative Regulation Of Muscle Cell Differentiation Regulation Of ATP Metabolic Process Response To Interleukin-1 Regulation Of Purine Nucleotide Metabolic Process Regulation Of Striated Muscle Cell Differentiation B Cell Differentiation Negative Regulation Of Small Molecule Metabolic Process Cell Surface Receptor Signaling Pathway Nucleosome Assembly Positive Regulation Of Post-translational Protein Modification Histone Deacetylase Binding Regulation Of Generation Of Precursor Metabolites And Energy Nucleosome Organization
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