MED16

Description		mediator complex subunit 16
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Nuclear Vitamin D Receptor Binding Nuclear Thyroid Hormone Receptor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Novel Interacting Genes		9 novel interacting genes: CEBPA CEBPE CTDP1 ESR1 ESR2 HNF4A LZTR1 MED9 MYC
Interacting Genes		9 interacting genes: CEBPA CEBPE CTDP1 ESR1 ESR2 HNF4A LZTR1 MED9 MYC
Entrez ID		10025
HPRD ID		06816
Ensembl ID		ENSG00000175221
Uniprot IDs		Q9Y2X0
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Nucleobase-containing Compound Biosynthetic Process Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nuclear Estrogen Receptor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nuclear Receptor Activity Chromatin Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Initiation Regulation Of RNA Biosynthetic Process Estrogen Response Element Binding Regulation Of RNA Metabolic Process RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Sequence-specific DNA Binding Nucleoplasm Nuclear Steroid Receptor Activity Estrogen Receptor Signaling Pathway Negative Regulation Of Cell Growth Intracellular Signal Transduction Steroid Binding Granulocyte Differentiation Nucleic Acid Metabolic Process Cellular Response To Estradiol Stimulus Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Growth Integrated Stress Response Signaling Intracellular Receptor Signaling Pathway DNA Binding Regulation Of Gene Expression Transcription Coregulator Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Macrophage Differentiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Metabolic Process
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