HCN4

Description		hyperpolarization activated cyclic nucleotide gated potassium channel 4
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GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Dendrite Monoatomic Ion Channel Complex Perinuclear Region Of Cytoplasm HCN Channel Complex
	Molecular Function	Nucleotide Binding Monoatomic Ion Channel Activity Intracellularly CAMP-activated Cation Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding CAMP Binding Identical Protein Binding Voltage-gated Potassium Channel Activity Involved In SA Node Cell Action Potential Depolarization
	Biological Process	Regulation Of Heart Rate Sinoatrial Node Development Regulation Of Membrane Depolarization Monoatomic Ion Transport Monoatomic Cation Transport Potassium Ion Transport Sodium Ion Transport Muscle Contraction Blood Circulation Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Transmembrane Transport Regulation Of Cardiac Muscle Contraction Cellular Response To CAMP Cellular Response To CGMP Potassium Ion Transmembrane Transport Membrane Depolarization During Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Sodium Ion Import Across Plasma Membrane Regulation Of SA Node Cell Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Potassium Ion Import Across Plasma Membrane
Pathways		HCN channels
Drugs
Diseases		Brugada syndrome (BRS) Sick sinus syndrome (SSS); Sinus node dysfunction
GWAS		Atrial fibrillation ( 22544366 30061737 29892015 28416818) Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart rate ( 23583979) Heart rate variability traits (pvRSA/HF) ( 28613276) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Heel bone mineral density ( 30598549) Nickel levels ( 26025379) PR interval ( 32439900) Resting heart rate ( 29769521 27798624) Triglyceride levels ( 32203549) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Novel Interacting Genes		2 novel interacting genes: HCN2 KCNE2
Interacting Genes		2 interacting genes: HCN2 KCNE2
Entrez ID		10021
HPRD ID		09240
Ensembl ID		ENSG00000138622
Uniprot IDs		Q9Y3Q4
PDB IDs		2MNG 3OTF 3U11 4HBN 4KL1 4NVP 6GYN 6GYO
Enriched GO Terms of Interacting Partners?		Voltage-gated Potassium Channel Activity Potassium Ion Import Across Plasma Membrane Potassium Channel Activity Inorganic Cation Import Across Plasma Membrane Voltage-gated Potassium Channel Complex Monoatomic Ion Channel Complex Import Across Plasma Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Response To Xenobiotic Stimulus HCN Channel Complex Cellular Response To CGMP Ammonium Transmembrane Transport Import Into Cell Monoatomic Cation Transmembrane Transport Metal Ion Transport Inorganic Cation Transmembrane Transport Regulation Of Membrane Potential Cellular Response To Aldosterone Intracellularly CAMP-activated Cation Channel Activity Response To CGMP Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Voltage-gated Potassium Channel Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity Cellular Response To Mineralocorticoid Stimulus Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Somatodendritic Compartment Membrane Depolarization During Cardiac Muscle Cell Action Potential Voltage-gated Sodium Channel Activity Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Inorganic Ion Transmembrane Transport Response To Aldosterone Ventricular Cardiac Muscle Cell Action Potential Potassium Ion Export Across Plasma Membrane CAMP Binding Membrane Depolarization During Action Potential Membrane Repolarization During Action Potential Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Delayed Rectifier Potassium Channel Activity Inward Rectifier Potassium Channel Activity Sodium Ion Import Across Plasma Membrane Monoatomic Ion Transport Negative Regulation Of Transporter Activity Membrane Repolarization
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