CDC27

Description		cell division cycle 27
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Mitotic Spindle
	Molecular Function	Protein Binding Protein Phosphatase Binding
	Biological Process	Metaphase/anaphase Transition Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Diffusing capacity of carbon monoxide ( 30694715) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		29 interacting genes: ADNP ANAPC10 ANAPC2 ANAPC4 ANAPC7 BUB1B CASP3 CDC16 CDC20 CDC26 CKS1B COMT CTNNB1 DCPS FZR1 GKN1 HOXC10 HSF2 MAD2L1 ORMDL3 PIN1 PPP5C PTEN PTTG1 RB1 SKIL SMAD2 SMAD3 UBE2S
Entrez ID		996
HPRD ID		00304
Ensembl ID		ENSG00000004897
Uniprot IDs		B4DL80 G5EA36 P30260
PDB IDs		3T1N 4RG6 4RG7 4RG9 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT
Enriched GO Terms of Interacting Partners?
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