KSR1

Description		kinase suppressor of ras 1
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Ruffle Membrane Protein-containing Complex
	Molecular Function	Protein Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Protein C-terminus Binding Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Signal Transduction Ras Protein Signal Transduction CAMP-mediated Signaling Regulation Of Cell Population Proliferation Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Systemic lupus erythematosus ( 28714469)
Interacting Genes		10 interacting genes: BRAP EPHB2 ITCH MAP2K1 MAPK1 MARK3 NME1 PJA2 RAF1 YWHAZ
Entrez ID		8844
HPRD ID		18980
Ensembl ID		ENSG00000141068
Uniprot IDs		Q8IVT5
PDB IDs		5VYK 7JUW 7JUX 7JUY 7JUZ 7JV0 7JV1
Enriched GO Terms of Interacting Partners?
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