ALG2

Description		ALG2 alpha-1,3/1,6-mannosyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Actin Cytoskeleton Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Alpha-1,3-mannosyltransferase Activity GDP-Man:Man1GlcNAc2-PP-Dol Alpha-1,3-mannosyltransferase Activity Protein Binding Protein Heterodimerization Activity Protein N-terminus Binding Calcium-dependent Protein Binding GDP-Man:Man2GlcNAc2-PP-dolichol Alpha-1,6-mannosyltransferase Activity
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Oligosaccharide-lipid Intermediate Biosynthetic Process Protein Glycosylation In Endoplasmic Reticulum Response To Calcium Ion Mannosylation
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG2 causes ALG2-CDG (CDG-1i)
Drugs
Diseases
GWAS		Asthma ( 31959851 34103634) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031)
Interacting Genes		4 interacting genes: ANXA11 PEF1 PTPN23 SRI
Entrez ID		85365
HPRD ID		09716
Ensembl ID		ENSG00000119523
Uniprot IDs		A0A024R184 Q9H553
PDB IDs
Enriched GO Terms of Interacting Partners?
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