NANOG

Description		Nanog homeobox
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Specification Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Stem Cell Population Maintenance Cell Differentiation Somatic Stem Cell Population Maintenance Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Stem Cell Proliferation
Pathways		POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases
GWAS
Interacting Genes		7 interacting genes: BRAF MED12 PRKCE RBPMS RHOXF2 SPOP USP21
Entrez ID		79923
HPRD ID		06397
Ensembl ID		ENSG00000111704
Uniprot IDs		A8K4D1 Q9H9S0
PDB IDs		2KT0 4RBO
Enriched GO Terms of Interacting Partners?
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