TBL1XR1

Description		TBL1X receptor 1
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GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Repressor Complex Mitotic Spindle
	Molecular Function	Transcription Cis-regulatory Region Binding Transcription Corepressor Activity Protein Binding Beta-catenin Binding Histone Binding Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Histone Deacetylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events Cytoprotection by HMOX1 Heme signaling
Drugs
Diseases
GWAS		Asthma ( 31959851 30929738 34103634 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms) ( 32595297) Central corneal thickness ( 32528159 31798171 29760442) Chin dimples ( 27182965) Chronotype ( 30696823) Corneal structure ( 23291589) Early chronic obstructive pulmonary disease in never smokers ( 33235445) Esophageal cancer ( 21642993) Inflammatory skin disease ( 25574825) Mastocytosis (KIT D816V positive) ( 33421400) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Pulse pressure ( 30224653) Red cell distribution width ( 32888494)
Interacting Genes		13 interacting genes: ARL2 CORO2A FOXK2 GPS2 H2BC21 H4C14 H4C6 HDAC3 MECP2 NCOR1 OGT TBL1X UBE2I
Entrez ID		79718
HPRD ID		15476
Ensembl ID		ENSG00000177565
Uniprot IDs		Q9BZK7
PDB IDs		4LG9
Enriched GO Terms of Interacting Partners?
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