D2HGDH

Description		D-2-hydroxyglutarate dehydrogenase
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix
	Molecular Function	Zinc Ion Binding (R)-2-hydroxyglutarate Dehydrogenase Activity FAD Binding
	Biological Process	2-oxoglutarate Metabolic Process Malate Metabolic Process Response To Manganese Ion Response To Zinc Ion Response To Cobalt Ion Response To Magnesium Ion Cellular Protein Metabolic Process Response To Calcium Ion
Pathways		Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
Drugs
Diseases
GWAS		Adult diffuse glioma (IDH mutation) ( 32386320) Adult diffuse glioma (IDH mutation, 1p/19q non-codeleted) ( 32386320) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Allergy ( 27182965) Artificially sweetened beverage consumption ( 31046077) Asthma ( 31361310 31959851 30929738 34103634 27182965 32296059 31619474) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Eczema ( 31361310) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Medication use (adrenergics, inhalants) ( 31015401) Medication use (antihistamines for systemic use) ( 31015401) Medication use (glucocorticoids) ( 31015401) Neutrophil percentage of granulocytes ( 27863252) Serum cancer antigen 125 levels ( 31666285) Serum metabolite levels ( 33031748) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		1 interacting genes: STK11
Entrez ID		728294
HPRD ID
Ensembl ID		ENSG00000180902
Uniprot IDs		B3KSR6 B4E3K7 B5MCV2 Q8N465
PDB IDs		6LPN 6LPP 6LPQ 6LPT 6LPU 6LPX
Enriched GO Terms of Interacting Partners?
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