TOP3A

Description		DNA topoisomerase III alpha
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Mitochondrial Matrix PML Body
	Molecular Function	DNA Binding Single-stranded DNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding Zinc Ion Binding
	Biological Process	DNA Topological Change Mitochondrial DNA Metabolic Process Chromosome Separation Meiotic Cell Cycle
Pathways		HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS		Systolic blood pressure ( 30224653)
Interacting Genes		3 interacting genes: BLM RECQL5 TDRD3
Entrez ID		7156
HPRD ID		03145
Ensembl ID		ENSG00000177302
Uniprot IDs		B4DSJ0 Q13472
PDB IDs		4CGY 4CHT
Enriched GO Terms of Interacting Partners?
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