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SPTBN2

Description spectrin beta, non-erythrocytic 2
Image
GO Annotations Cellular Component
  • Extracellular Space
  • Cytosol
  • Plasma Membrane
  • Spectrin
  • Apical Plasma Membrane
  • Cell Junction
  • Cortical Actin Cytoskeleton
  • Cell Projection
  • Neuronal Cell Body
  • Parallel Fiber To Purkinje Cell Synapse
  • Presynapse
  • Glutamatergic Synapse
  • Postsynaptic Spectrin-associated Cytoskeleton
Molecular Function
  • Actin Binding
  • Structural Constituent Of Cytoskeleton
  • Phospholipid Binding
  • Cadherin Binding
  • Actin Filament Binding
  • Structural Constituent Of Synapse
Biological Process
  • Cytoskeleton Organization
  • Synapse Assembly
  • Vesicle-mediated Transport
  • Cerebellar Purkinje Cell Layer Morphogenesis
  • Actin Cytoskeleton Organization
  • Adult Behavior
  • Multicellular Organism Growth
  • Actin Filament Capping
  • Postsynapse Organization
Pathways
  • MHC class II antigen presentation
  • NCAM signaling for neurite out-growth
  • NCAM signaling for neurite out-growth
  • Interaction between L1 and Ankyrins
  • Interaction between L1 and Ankyrins
  • RAF/MAP kinase cascade
  • COPI-mediated anterograde transport
Drugs
Diseases
GWAS
  • Bipolar disorder ( 28115744 21926972 31043756)
  • Hip circumference adjusted for BMI ( 34021172)
  • Major depressive disorder (MTAG) ( 33479212)
Interacting Genes 11 interacting genes: ACTA1 ACTB ACTR1A ADRB2 APC CELSR3 DCTN1 MINK1 SPTA1 SPTAN1 UNC13B
Entrez ID 6712
HPRD ID 05404
Ensembl ID ENSG00000173898
Uniprot IDs O15020
PDB IDs 1WJM 1WYQ 6ANU
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025