ST3GAL4

Description		ST3 beta-galactoside alpha-2,3-sialyltransferase 4
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Membrane Integral Component Of Membrane Golgi Cisterna Membrane
	Molecular Function	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Neolactotetraosylceramide Alpha-2,3-sialyltransferase Activity N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity Monosialoganglioside Sialyltransferase Activity
	Biological Process	Protein Glycosylation Glycoprotein Biosynthetic Process Glycolipid Biosynthetic Process Oligosaccharide Biosynthetic Process O-glycan Processing Keratan Sulfate Biosynthetic Process Viral Protein Processing Positive Regulation Of Blood Coagulation Lipid Glycosylation Cognition Sialylation Positive Regulation Of Leukocyte Tethering Or Rolling Protein Sialylation
Pathways		Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a N-Glycan antennae elongation Termination of O-glycan biosynthesis
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 29875488) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 25961943 20686565) Coronary artery disease ( 29212778) Factor VIII levels ( 30586737) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 31562340) High light scatter reticulocyte count ( 32888494) LDL cholesterol ( 24097068 30275531 25961943 20686565) LDL cholesterol levels ( 32203549 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 33972514 22001757) Low density lipoprotein cholesterol levels ( 32154731 33339817) Mean platelet volume ( 32888494 27863252) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 23823483) Monocyte count ( 32888494) Mumps ( 28928442) N-glycan levels ( 31163085) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301 31666285 29403010 33339817) Soluble E-selectin levels ( 31217265) Total cholesterol levels ( 28334899 33339817 30275531) vWF levels ( 30586737)
Interacting Genes		3 interacting genes: ARHGDIA CD8B GGCX
Entrez ID		6484
HPRD ID		00084
Ensembl ID		ENSG00000110080
Uniprot IDs		A0A7I2V5F3 Q11206 Q6IBE6
PDB IDs
Enriched GO Terms of Interacting Partners?
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