SCN10A

Description		sodium voltage-gated channel alpha subunit 10
Image		No pdb structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Axon Extracellular Exosome Clathrin Complex Glutamatergic Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Transmembrane Transporter Binding
	Biological Process	Regulation Of Heart Rate Sensory Perception Neuronal Action Potential Sensory Perception Of Pain Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Odontogenesis Of Dentin-containing Tooth Regulation Of Cardiac Muscle Contraction Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Membrane Depolarization During Action Potential AV Node Cell Action Potential Bundle Of His Cell Action Potential
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs		Ranolazine Topiramate Lidocaine Ropivacaine Bupivacaine Valproic acid Hexylcaine Cinchocaine Lamotrigine Carbamazepine Dyclonine Procaine Oxcarbazepine Proparacaine Oxybuprocaine Cocaine Mepivacaine Levobupivacaine Promethazine Benzocaine Chloroprocaine Orphenadrine Brivaracetam Lacosamide Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Atrioventricular conduction ( 21041692) Brugada syndrome ( 23872634 32619740) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic conduction measures ( 23463857) Electrocardiographic traits ( 20062061 20062063 25055868) Electrocardiographic traits (multivariate) ( 32602732) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) P wave duration ( 28794112 24850809) Physical health related quality of life ( 33578652) PR interval ( 30679814 29127183 30046033 32439900 20062060 25035420 23139255 21347284) PR segment duration ( 24850809) Pulse pressure ( 30224653 30578418) QRS duration ( 30679814 27577874 31251759 30012220 25035420 21076409 27659466) QT interval ( 24952745 29874175) Sick sinus syndrome ( 33580673) Systemic lupus erythematosus ( 23273568) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149)
Interacting Genes		2 interacting genes: ACTB SCLT1
Entrez ID		6336
HPRD ID		09188
Ensembl ID		ENSG00000185313
Uniprot IDs		Q9Y5Y9
PDB IDs
Enriched GO Terms of Interacting Partners?
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