SPHK2

Description		sphingosine kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Lysosomal Membrane Endoplasmic Reticulum Cytosol Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Lipid Kinase Activity NAD+ Kinase Activity Protein Binding ATP Binding Sphinganine Kinase Activity D-erythro-sphingosine Kinase Activity Small GTPase Binding Nucleosomal Histone Binding Sphingosine-1-phosphate Receptor Activity
	Biological Process	Blood Vessel Development Positive Regulation Of Cytokine Production Involved In Immune Response Sphingosine-1-phosphate Receptor Signaling Pathway Sphingolipid Metabolic Process Sphinganine-1-phosphate Biosynthetic Process Sphingosine Metabolic Process Brain Development Female Pregnancy Positive Regulation Of Cell Population Proliferation Phosphorylation Sphingolipid Biosynthetic Process Negative Regulation Of Cell Growth Negative Regulation Of Histone Deacetylation Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Mast Cell Activation Involved In Immune Response Positive Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Mast Cell Degranulation Histone H2A-K5 Acetylation Histone H2B-K12 Acetylation Positive Regulation Of Gene Expression, Epigenetic Sphingosine Biosynthetic Process Lipid Phosphorylation Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Calcium Ion Import Negative Regulation Of Histone Deacetylase Activity Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Phorbol 13-acetate 12-myristate Regulation Of Cytochrome-c Oxidase Activity Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Histone H3-K9 Acetylation Regulation Of ATP Biosynthetic Process
Pathways		Sphingolipid de novo biosynthesis
Drugs		Opaganib
Diseases
GWAS		Bipolar disorder ( 21926972) Crohn's disease ( 23128233) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Psoriasis ( 31376382) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: BCL2 FYN LYN
Entrez ID		56848
HPRD ID		06157
Ensembl ID		ENSG00000063176
Uniprot IDs		A0A024QZH5 B3KV83 E9PCV4 Q9NRA0
PDB IDs
Enriched GO Terms of Interacting Partners?
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