PRKG2

Description		protein kinase cGMP-dependent 2
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GO Annotations	Cellular Component	Cytosol Apical Plasma Membrane Nuclear Membrane
	Molecular Function	Protein Kinase Activity CGMP-dependent Protein Kinase Activity ATP Binding CGMP Binding Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Signal Transduction Peptidyl-serine Autophosphorylation Tetrahydrobiopterin Metabolic Process Protein Localization To Plasma Membrane Negative Regulation Of Chloride Transport
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Ca2+ pathway cGMP effects cGMP effects RAS processing
Drugs		Fostamatinib
Diseases
GWAS		Blood pressure (smoking interaction) ( 25189868) Body size at age 10 ( 32376654) Height ( 28552196 25282103 19343178 23563607 31562340 18391951 33713608) Hip circumference adjusted for BMI ( 34021172 25673412) HIV-1 susceptibility ( 22174851) Pubertal anthropometrics ( 23449627) Refractive error ( 32231278) Schizophrenia ( 33169155) Sleep duration (short sleep) ( 30846698) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500)
Interacting Genes		7 interacting genes: FBXO25 LASP1 MYLK NEDD4 PLCB3 PTS WDR77
Entrez ID		5593
HPRD ID		09034
Ensembl ID		ENSG00000138669
Uniprot IDs		A0A140VJM3 B4DLF9 B7ZA25 Q13237
PDB IDs		5BV6 5C6C 5C8W 5JIX 5JIZ 6BQ8
Enriched GO Terms of Interacting Partners?
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