PPP2R5E

Description		protein phosphatase 2 regulatory subunit B'epsilon
Image		No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity
	Biological Process	Protein Dephosphorylation Signal Transduction Regulation Of Catalytic Activity
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 32154731) Response to antineoplastic agents ( 21659360) Schizophrenia ( 33169155) Systolic blood pressure ( 28135244) Triglyceride levels ( 32154731)
Interacting Genes		22 interacting genes: APP BHLHB9 BHLHE41 CHEK2 CLOCK CRY1 CRY2 CSNK1E CSNK2B CTNNA3 DELEC1 DOCK9 ENO1 FBXW11 OGT PPP1CA PPP2CA PPP2R1B RACGAP1 RORC SGO1 SMAD9
Entrez ID		5529
HPRD ID		09040
Ensembl ID		ENSG00000154001
Uniprot IDs		Q16537
PDB IDs
Enriched GO Terms of Interacting Partners?
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