PIK3CB

Description		phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Membrane Midbody Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol Kinase Activity Phosphatidylinositol-3,4-bisphosphate 5-kinase Activity
	Biological Process	Regulation Of Cell-matrix Adhesion Response To Ischemia Sphingosine-1-phosphate Receptor Signaling Pathway Endocytosis Autophagy Chemotaxis Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Phosphatidylinositol 3-kinase Signaling Phosphorylation Cell Migration Platelet Activation Positive Regulation Of Neutrophil Apoptotic Process Positive Regulation Of Rac Protein Signal Transduction Phosphatidylinositol-3-phosphate Biosynthetic Process Negative Regulation Of MAP Kinase Activity Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Platelet Aggregation Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Regulation Of Clathrin-dependent Endocytosis
Pathways		PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Downstream signal transduction PI3K/AKT activation Signaling by ALK Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants
Drugs		Caffeine XL765
Diseases
GWAS		Male-pattern baldness ( 28196072) Mean platelet volume ( 32888494)
Interacting Genes		12 interacting genes: AGTR2 ALAS1 DVL3 HCK HPS6 LRRK2 MME PIK3R1 PRKCD PRKCE RAB5B YWHAQ
Entrez ID		5291
HPRD ID		04234
Ensembl ID		ENSG00000051382
Uniprot IDs		B4DER4 B4DZI3 P42338
PDB IDs
Enriched GO Terms of Interacting Partners?
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