PDE4A

Description		phosphodiesterase 4A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding CAMP Binding Metal Ion Binding
	Biological Process	CAMP Catabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Smell Regulation Of Protein Kinase A Signaling Regulation Of CAMP-mediated Signaling Cellular Response To Xenobiotic Stimulus
Pathways		DARPP-32 events G alpha (s) signalling events
Drugs		Caffeine Theophylline Dyphylline Enprofylline Dipyridamole Iloprost Oxtriphylline Amrinone Roflumilast Piclamilast Crisaborole Ibudilast Propentofylline Drotaverine (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Tofisopam Trapidil
Diseases
GWAS		Blood protein levels ( 28240269) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) LDL cholesterol levels in HIV infection ( 33109212) Multiple sclerosis ( 31604244) Plateletcrit ( 32888494)
Interacting Genes		7 interacting genes: AIP CYB561D2 LYN OSGIN1 PFKFB1 PIAS4 SMARCA4
Entrez ID		5141
HPRD ID		02527
Ensembl ID		ENSG00000065989
Uniprot IDs		P27815
PDB IDs		2QYK 3I8V 3TVX
Enriched GO Terms of Interacting Partners?
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