SHANK1

Description		SH3 and multiple ankyrin repeat domains 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Membrane Dendrite Neuron Projection Dendritic Spine Postsynaptic Membrane Excitatory Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding Protein C-terminus Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Somatostatin Receptor Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Ankyrin Repeat Binding Scaffold Protein Binding
	Biological Process	Long-term Memory Associative Learning Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Olfactory Behavior Habituation Neuromuscular Process Controlling Balance Determination Of Affect Righting Reflex Synapse Maturation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Vocalization Behavior Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Carotid plaque maximum area ( 32469969) Clozapine-induced cytotoxicity ( 25656473) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969)
Interacting Genes		22 interacting genes: ABCA1 ACE2 ADGRB2 ADGRL1 ADGRL2 ARHGEF7 BAIAP2 DLG4 DLGAP1 DNM2 FXR1 HOMER1 RPS6KA2 RPS6KA3 SHANK3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1 TSC1 USP8
Entrez ID		50944
HPRD ID		05413
Ensembl ID		ENSG00000161681
Uniprot IDs		H9KV90 Q9Y566
PDB IDs		6CPI 6YWZ 6YX0 6YX1 6YX2
Enriched GO Terms of Interacting Partners?
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