NTHL1

Description		nth like DNA glycosylase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Oxidized Pyrimidine Nucleobase Lesion DNA N-glycosylase Activity Damaged DNA Binding Double-stranded DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endonuclease Activity Protein Binding Oxidized Purine Nucleobase Lesion DNA N-glycosylase Activity DNA N-glycosylase Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	Base-excision Repair, AP Site Formation Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Depyrimidination
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1 Defective NTHL1 substrate processing Defective NTHL1 substrate binding
Drugs
Diseases
GWAS		Adult body size ( 32376654) Longevity ( 20834067)
Interacting Genes		6 interacting genes: ERCC5 PCNA PKD1 RBX1 SRPK2 TP53
Entrez ID		4913
HPRD ID		04039
Ensembl ID		ENSG00000065057
Uniprot IDs		E5KTI5 P78549
PDB IDs
Enriched GO Terms of Interacting Partners?
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