SLC11A2

Description		solute carrier family 11 member 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lysosomal Membrane Early Endosome Vacuole Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Cytoplasmic Vesicle Brush Border Membrane Late Endosome Membrane Apical Part Of Cell Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Paraferritin Complex Extracellular Vesicle
	Molecular Function	Copper Ion Transmembrane Transporter Activity Iron Ion Transmembrane Transporter Activity Manganese Ion Transmembrane Transporter Activity Protein Binding Cadmium Ion Transmembrane Transporter Activity Cobalt Ion Transmembrane Transporter Activity Ferrous Iron Transmembrane Transporter Activity Lead Ion Transmembrane Transporter Activity Nickel Cation Transmembrane Transporter Activity Solute:proton Symporter Activity Cadmium Ion Binding Transition Metal Ion Transmembrane Transporter Activity
	Biological Process	Response To Hypoxia Heme Biosynthetic Process Cobalt Ion Transport Copper Ion Transport Iron Ion Transport Manganese Ion Transport Cellular Iron Ion Homeostasis Learning Or Memory Response To Iron Ion Lead Ion Transport Iron Import Into Cell Iron Ion Transmembrane Transport Copper Ion Transmembrane Transport Nickel Cation Transmembrane Transport Dendrite Morphogenesis Erythrocyte Development Multicellular Organismal Iron Ion Homeostasis Cadmium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Proton Transmembrane Transport
Pathways		Metal ion SLC transporters Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) Iron uptake and transport
Drugs		Ferric maltol
Diseases
GWAS		Iron status biomarkers (ferritin levels) ( 33536631)
Interacting Genes		2 interacting genes: PRIM1 VPS35
Entrez ID		4891
HPRD ID		02750
Ensembl ID		ENSG00000110911
Uniprot IDs		A0A0X8GKR4 P49281
PDB IDs		5F0L 5F0M 5F0P
Enriched GO Terms of Interacting Partners?
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