LMNB1

Description		lamin B1
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Lamin Filament Nucleoplasm Cytosol Membrane Nuclear Matrix Nuclear Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Phospholipase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process
Pathways		Meiotic synapsis Formation of Senescence-Associated Heterochromatin Foci (SAHF) Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Breakdown of the nuclear lamina Depolymerisation of the Nuclear Lamina Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation RHOD GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Body fat percentage ( 31752434) Parkinson's disease (motor and cognition) ( 22658654)
Interacting Genes		42 interacting genes: ABCG8 ATF4 CASP3 CASP6 CCDC88B CDK1 CENPH DMAP1 FAM169A GABARAP GIT2 GZMA GZMB KPNA5 KPNA6 LBR LMNA M1AP MAP1LC3A MAP1LC3C MBIP MELK PIAS2 PIH1D2 PLEC PPP1R13B PRKCA PRKCB PRKCD PRPH PTEN RNF123 SERPINA3 SNAPIN SRPK2 SUMO4 TMPO TOR1AIP1 TP53BP2 UBE2I URB2 YWHAQ
Entrez ID		4001
HPRD ID		01036
Ensembl ID		ENSG00000113368
Uniprot IDs		B4DZT3 P20700
PDB IDs		2KPW 3JT0 3TYY 3UMN 5VVX
Enriched GO Terms of Interacting Partners?
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