IL12RB2

Description		interleukin 12 receptor subunit beta 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Receptor Complex
	Molecular Function	Cytokine Receptor Activity Protein Kinase Binding Cytokine Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Positive Regulation Of Interferon-gamma Production
Pathways		Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling
Drugs
Diseases
GWAS		Behcet's disease ( 20622878 20622879) Blood protein levels ( 30072576 29875488) Crohn's disease ( 28067908 22412388) Crohn's disease or systemic sclerosis ( 32024964) Inflammatory bowel disease ( 28067908 23128233) Medication use (thyroid preparations) ( 31015401) Primary biliary cholangitis ( 19458352 21399635 20639880 26394269) Rheumatoid arthritis ( 32868391) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699) Systemic lupus erythematosus ( 33536424 26502338 28714469 19838195) Systemic sclerosis ( 31672989 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Type 2 diabetes (age of onset) ( 28060188) Ulcerative colitis ( 28067908)
Interacting Genes		5 interacting genes: IL12B IL12RB1 JAK2 SOCS3 STAT4
Entrez ID		3595
HPRD ID		03383
Ensembl ID		ENSG00000081985
Uniprot IDs		A0A0A0MTN7 B4DGA4 B7ZB60 Q99665
PDB IDs
Enriched GO Terms of Interacting Partners?
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