IGFBP1

Description		insulin like growth factor binding protein 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus
	Molecular Function	Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Signal Transduction Aging Insulin Receptor Signaling Pathway Positive Regulation Of Cell Growth Tissue Regeneration Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs
Diseases
GWAS		Major depressive disorder ( 23377640) Night sleep phenotypes ( 27126917) Offspring birth weight ( 31043758) Poor prognosis in Crohn's disease ( 28067912) Pulse pressure ( 28135244 30487518) Rheumatoid arthritis ( 21156761) Subjective response to lithium treatment in bipolar disorder ( 26503763) Systolic blood pressure ( 27618447)
Interacting Genes		4 interacting genes: IGF1 IGF2 MMP26 TF
Entrez ID		3484
HPRD ID		00897
Ensembl ID		ENSG00000146678
Uniprot IDs		P08833
PDB IDs		1ZT3 1ZT5 2DSQ
Enriched GO Terms of Interacting Partners?
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