AIRE

Description		autoimmune regulator
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GO Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding Translation Regulator Activity
	Biological Process	Peripheral T Cell Tolerance Induction Central Tolerance Induction To Self Antigen Regulation Of Transcription, DNA-templated Regulation Of Translation Immune Response Humoral Immune Response Positive Regulation Of Chemokine Production Negative Thymic T Cell Selection Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Thymus Epithelium Morphogenesis Regulation Of Thymocyte Migration
Pathways
Drugs
Diseases
GWAS		Addison's disease ( 33574239) Dental caries (decayed, missing and filled teeth) ( 31533690) Rheumatoid arthritis ( 21505073 30423114) Type 1 diabetes ( 34012112)
Interacting Genes		6 interacting genes: CREBBP DAXX H2BC21 H3C1 PTTG1IP UBAC1
Entrez ID		326
HPRD ID		06301
Ensembl ID		ENSG00000160224
Uniprot IDs		O43918
PDB IDs		1XWH 2KE1 2KFT 2LRI
Enriched GO Terms of Interacting Partners?
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