HiPPIP
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HCRT
Description
hypocretin neuropeptide precursor
Image
GO Annotations
Cellular Component
Extracellular Region
Rough Endoplasmic Reticulum
Synaptic Vesicle
Secretory Granule
Perinuclear Region Of Cytoplasm
Postsynapse
Molecular Function
Neuropeptide Hormone Activity
Type 1 Hypocretin Receptor Binding
Type 2 Hypocretin Receptor Binding
Biological Process
Temperature Homeostasis
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway
Neuropeptide Signaling Pathway
Chemical Synaptic Transmission
Negative Regulation Of DNA Replication
Sleep
Response To Starvation
Eating Behavior
Negative Regulation Of Potassium Ion Transport
Regulation Of Neurotransmitter Secretion
Positive Regulation Of Calcium Ion Transport
Negative Regulation Of Transmission Of Nerve Impulse
Positive Regulation Of Transmission Of Nerve Impulse
Excitatory Postsynaptic Potential
Positive Regulation Of Cold-induced Thermogenesis
Pathways
Orexin and neuropeptides FF and QRFP bind to their respective receptors
G alpha (q) signalling events
Drugs
Pidolic acid
Diseases
GWAS
Interacting Genes
3 interacting genes:
HCRTR1
HCRTR2
NPFFR2
Entrez ID
3060
HPRD ID
03836
Ensembl ID
ENSG00000161610
Uniprot IDs
O43612
PDB IDs
1CQ0
1R02
1UVQ
1WSO
7L1U
Enriched GO Terms of Interacting Partners
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