GOT1

Description		glutamic-oxaloacetic transaminase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol Axon Terminus Extracellular Exosome
	Molecular Function	L-aspartate:2-oxoglutarate Aminotransferase Activity Phosphatidylserine Decarboxylase Activity Pyridoxal Phosphate Binding Carboxylic Acid Binding L-cysteine:2-oxoglutarate Aminotransferase Activity
	Biological Process	2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Glycerol Biosynthetic Process Aspartate Metabolic Process Aspartate Biosynthetic Process Aspartate Catabolic Process Glutamate Metabolic Process Notch Signaling Pathway Response To Carbohydrate Glutamate Catabolic Process To Aspartate Glutamate Catabolic Process To 2-oxoglutarate Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Insulin Stimulus Negative Regulation Of Collagen Biosynthetic Process Response To Immobilization Stress Response To Cadmium Ion Response To Glucocorticoid Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Mitochondrial Depolarization Fatty Acid Homeostasis Transdifferentiation Cellular Response To Mechanical Stimulus Response To Transition Metal Nanoparticle
Pathways		Methionine salvage pathway Gluconeogenesis Aspartate and asparagine metabolism
Drugs		Pyridoxal phosphate Aspartic acid Glutamic acid Cysteine Adapalene Maleic Acid Copper
Diseases
GWAS		Aspartate aminotransferase levels ( 30718733 21900944) Crohn's disease ( 22412388) Hypothyroidism ( 27182965) Liver enzyme levels (aspartate transaminase) ( 24124411) Mean corpuscular volume ( 29403010) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		7 interacting genes: ABI3BP AGTR1 CCR2 EGFR PC SHANK3 TMEM120A
Entrez ID		2805
HPRD ID		00687
Ensembl ID		ENSG00000120053
Uniprot IDs		A0A140VK69 P17174
PDB IDs		3II0 3WZF 6DNA 6DNB 6DND 6LIG
Enriched GO Terms of Interacting Partners?
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