IL37

Description		interleukin 37
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Protein Binding
	Biological Process	Inflammatory Response To Antigenic Stimulus Inflammatory Response Immune Response Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Inflammatory Response Cellular Response To Lipopolysaccharide
Pathways		Interleukin-37 signaling Interleukin-18 signaling
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Dysmenorrheic pain severity ( 29855537) Menstruation quality of life impact (dysmenorrhea) ( 29855537) Pain medicine use during menstruation ( 29855537) Pulmonary function ( 23932459) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482)
Interacting Genes		8 interacting genes: CASP1 CASP4 IL18BP IL18R1 PRKAB2 SMAD3 TRIM55 TRIM63
Entrez ID		27178
HPRD ID		05695
Ensembl ID		ENSG00000125571
Uniprot IDs		Q9NZH6
PDB IDs		5HN1 6NCU
Enriched GO Terms of Interacting Partners?
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