EIF2AK1

Description		eukaryotic translation initiation factor 2 alpha kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm
	Molecular Function	Protein Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Binding ATP Binding Heme Binding Protein Homodimerization Activity Protein Serine Kinase Activity
	Biological Process	Acute Inflammatory Response Phagocytosis Negative Regulation Of Cell Population Proliferation Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Regulation Of EIF2 Alpha Phosphorylation By Heme Macrophage Differentiation Negative Regulation Of Translational Initiation By Iron Protoporphyrinogen IX Metabolic Process Protein Autophosphorylation Negative Regulation Of Hemoglobin Biosynthetic Process Iron Ion Homeostasis Integrated Stress Response Signaling HRI-mediated Signaling Response To Iron Ion Starvation
Pathways		Response of EIF2AK1 (HRI) to heme deficiency
Drugs		Fostamatinib
Diseases
GWAS		High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		5 interacting genes: CDC37 EIF2S1 HSP90AA1 LIG4 SELENOS
Entrez ID		27102
HPRD ID		10684
Ensembl ID		ENSG00000086232
Uniprot IDs		A0A024QZU1 Q9BQI3
PDB IDs
Enriched GO Terms of Interacting Partners?
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