GBA

Description		glucosylceramidase beta
Image
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Extrinsic Component Of Membrane Lysosomal Lumen Extracellular Exosome
	Molecular Function	Glucosylceramidase Activity Signaling Receptor Binding Scavenger Receptor Binding Protein Binding Glucosyltransferase Activity Steryl-beta-glucosidase Activity
	Biological Process	Glucosylceramide Catabolic Process Autophagy Mitochondrion Organization Lysosome Organization Cholesterol Metabolic Process Determination Of Adult Lifespan Cellular Response To Starvation Response To PH Microglia Differentiation Regulation Of Macroautophagy Antigen Processing And Presentation Lipid Storage Cerebellar Purkinje Cell Layer Formation Pyramidal Neuron Differentiation Respiratory Electron Transport Chain Termination Of Signal Transduction Lipid Glycosylation Neuron Projection Development Negative Regulation Of Protein-containing Complex Assembly Regulation Of TOR Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interleukin-6 Production T Cell Differentiation In Thymus Regulation Of Water Loss Via Skin Response To Testosterone Positive Regulation Of Protein Dephosphorylation Cell Death In Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein-containing Complex Disassembly Negative Regulation Of MAP Kinase Activity Negative Regulation Of Neuron Apoptotic Process Skin Morphogenesis Response To Estrogen Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Cell Maturation Brain Morphogenesis Homeostasis Of Number Of Cells Negative Regulation Of Inflammatory Response Neuromuscular Process Positive Regulation Of Protein Metabolic Process Neuron Apoptotic Process Microglial Cell Proliferation Motor Behavior Cellular Response To Tumor Necrosis Factor Hematopoietic Stem Cell Proliferation Response To Dexamethasone Lymphocyte Migration Response To Thyroid Hormone Negative Regulation Of Neuron Death Beta-glucoside Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Protein Lipidation Positive Regulation Of Neuronal Action Potential Positive Regulation Of Autophagy Of Mitochondrion In Response To Mitochondrial Depolarization Autophagosome Organization Regulation Of Lysosomal Protein Catabolic Process
Pathways		Glycosphingolipid metabolism Association of TriC/CCT with target proteins during biosynthesis
Drugs		scyllo-inositol N-acetyl-alpha-D-glucosamine Velaglucerase alfa (2R,3R,4R,5S)-2-(HYDROXYMETHYL)-1-NONYLPIPERIDINE-3,4,5-TRIOL
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Dementia with Lewy bodies ( 29263008 31065058) Inflammatory bowel disease ( 28067908) Intracranial aneurysm ( 30823506) Parkinson's disease ( 22451204 25064009 27182965 24842889 28892059 21738487) Renal function-related traits (BUN) ( 22797727) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		5 interacting genes: MLF1 NEDD4 OGT PSAP SNCA
Entrez ID		2629
HPRD ID		06973
Ensembl ID		ENSG00000177628
Uniprot IDs		A0A068F658 B7Z6S9 P04062
PDB IDs		1OGS 1Y7V 2F61 2J25 2NSX 2NT0 2NT1 2V3D 2V3E 2V3F 2VT0 2WCG 2WKL 2XWD 2XWE 3GXD 3GXF 3GXI 3GXM 3KE0 3KEH 3RIK 3RIL 5LVX 6MOZ 6Q1N 6Q1P 6Q6K 6Q6L 6Q6N 6TJJ 6TJK 6TJQ 6TN1
Enriched GO Terms of Interacting Partners?
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