ANAPC15

Description		anaphase promoting complex subunit 15
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GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Protein Binding
	Biological Process	Cell Cycle Cell Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects
Drugs
Diseases
GWAS
Interacting Genes		4 interacting genes: ABL1 CDKN2A CEP19 PDE2A
Entrez ID		25906
HPRD ID		13172
Ensembl ID		ENSG00000110200
Uniprot IDs		A0A024R5G0 G5EA39 P60006
PDB IDs		4UI9 5A31 5G04 5G05 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT
Enriched GO Terms of Interacting Partners?
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