ORC6

Description		origin recognition complex subunit 6
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GO Annotations	Cellular Component	Origin Recognition Complex Fibrillar Center Nucleoplasm Nuclear Origin Of Replication Recognition Complex Membrane
	Molecular Function	DNA Binding Protein Binding
	Biological Process	DNA Replication Initiation Negative Regulation Of Cell Division
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS
Interacting Genes		19 interacting genes: APP CDC45 CDC6 CDC7 DBF4 HMGA1 LHX4 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RPA1 SPAG5 TERF2
Entrez ID		23594
HPRD ID		06237
Ensembl ID		ENSG00000091651
Uniprot IDs		A0A024R6R3 Q9Y5N6
PDB IDs		3M03 6KVG
Enriched GO Terms of Interacting Partners?
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