SIRT5

Description		sirtuin 5
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GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Cytosol
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Zinc Ion Binding NAD-dependent Protein Deacetylase Activity Protein-malonyllysine Demalonylase Activity Protein-succinyllysine Desuccinylase Activity Protein-glutaryllysine Deglutarylase Activity NAD+ Binding
	Biological Process	Protein ADP-ribosylation Protein Deacetylation Mitochondrion Organization Regulation Of Ketone Biosynthetic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Nutrient Levels Protein Demalonylation Peptidyl-lysine Demalonylation Protein Desuccinylation Peptidyl-lysine Desuccinylation Protein Deglutarylation Peptidyl-lysine Deglutarylation Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Transcriptional activation of mitochondrial biogenesis
Drugs		Adenosine-5-Diphosphoribose Nicotinamide 2'-O-Acetyl Adenosine-5-Diphosphoribose Suramin Cambinol
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Perceived intensity of sweet substances ( 31005972)
Interacting Genes		3 interacting genes: APP LSS RNF182
Entrez ID		23408
HPRD ID		06838
Ensembl ID		ENSG00000124523
Uniprot IDs		A0A024R012 Q9NXA8
PDB IDs		2B4Y 2NYR 3RIG 3RIY 4F4U 4F56 4G1C 4HDA 5BWL 5XHS 6ACE 6ACL 6ACO 6ACP 6EQS 6LJK 6LJM 6LJN
Enriched GO Terms of Interacting Partners?
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