PSME4

Description		proteasome activator subunit 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Speck Spermatoproteasome Complex
	Molecular Function	Protein Binding Peptidase Activator Activity Lysine-acetylated Histone Binding Proteasome Binding
	Biological Process	DNA Repair Cellular Response To DNA Damage Stimulus Proteasomal Ubiquitin-independent Protein Catabolic Process Positive Regulation Of Peptidase Activity Spermatogenesis, Exchange Of Chromosomal Proteins
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis ROS sensing by NFE2L2 RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 28892062) Chronotype ( 30696823 27494321) Hand grip strength ( 29691431) Morning vs. evening chronotype ( 27494321) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: CALCOCO2 FBXL17 H4C1 HTT MTNR1A NUTM1
Entrez ID		23198
HPRD ID		09652
Ensembl ID		ENSG00000068878
Uniprot IDs		Q14997
PDB IDs		6KWX 6KWY 6REY
Enriched GO Terms of Interacting Partners?
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