FASN

Description		fatty acid synthase
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Melanosome Glycogen Granule Extracellular Exosome
	Molecular Function	RNA Binding Fatty Acid Synthase Activity [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity 3-oxoacyl-[acyl-carrier-protein] Synthase Activity 3-oxoacyl-[acyl-carrier-protein] Reductase (NADPH) Activity 3-hydroxypalmitoyl-[acyl-carrier-protein] Dehydratase Activity Oleoyl-[acyl-carrier-protein] Hydrolase Activity Protein Binding (3R)-hydroxymyristoyl-[acyl-carrier-protein] Dehydratase Activity 3-hydroxydecanoyl-[acyl-carrier-protein] Dehydratase Activity Myristoyl-[acyl-carrier-protein] Hydrolase Activity Palmitoyl-[acyl-carrier-protein] Hydrolase Activity Phosphopantetheine Binding Identical Protein Binding Cadherin Binding Enoyl-[acyl-carrier-protein] Reductase (NADPH, A-specific) Activity 3-hydroxyoctanoyl-[acyl-carrier-protein] Dehydratase Activity
	Biological Process	Osteoblast Differentiation Glandular Epithelial Cell Development Acetyl-CoA Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Ether Lipid Biosynthetic Process Neutrophil Differentiation Monocyte Differentiation Mammary Gland Development Cellular Response To Interleukin-4 Establishment Of Endothelial Intestinal Barrier
Pathways		ChREBP activates metabolic gene expression Vitamin B5 (pantothenate) metabolism Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
Drugs		Cerulenin Orlistat
Diseases
GWAS		Blood protein levels ( 30072576) Major depressive disorder ( 27777418) Malate levels ( 31560688) Refractive error ( 32231278)
Interacting Genes		14 interacting genes: ADIPOQ AKT1 ASXL1 BIRC5 DUX4 EWSR1 HSP90AA1 LNX1 MTDH NDRG1 PRR12 PTEN SUMO2 YWHAQ
Entrez ID		2194
HPRD ID		02567
Ensembl ID		ENSG00000169710
Uniprot IDs		P49327
PDB IDs		1XKT 2CG5 2JFD 2JFK 2PX6 3HHD 3TJM 4PIV 4W82 4W9N 4Z49 5C37 6NNA
Enriched GO Terms of Interacting Partners?
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