ALAD

Description		aminolevulinate dehydratase
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Catalytic Activity Porphobilinogen Synthase Activity Zinc Ion Binding Identical Protein Binding Proteasome Core Complex Binding
	Biological Process	Response To Hypoxia Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Response To Oxidative Stress Response To Xenobiotic Stimulus Response To Herbicide Response To Iron Ion Response To Zinc Ion Response To Aluminum Ion Response To Ionizing Radiation Response To Vitamin B1 Response To Selenium Ion Response To Activity Response To Cobalt Ion Response To Lipopolysaccharide Response To Vitamin E Response To Amino Acid Response To Ethanol Response To Arsenic-containing Substance Response To Cadmium Ion Response To Mercury Ion Protein Homooligomerization Response To Glucocorticoid Response To Methylmercury Response To Platinum Ion Response To Fatty Acid Cellular Response To Lead Ion Cellular Response To Interleukin-4 Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways		Heme biosynthesis Neutrophil degranulation
Drugs		Aminolevulinic acid Delta-Amino Valeric Acid Laevulinic Acid 4-Oxosebacic Acid Porphobilinogen 3-(2-Aminoethyl)-4-(Aminomethyl)Heptanedioic Acid 4,7-Dioxosebacic Acid 5-hydroxyvaleric acid
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lead levels in blood ( 25820613) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		1 interacting genes: POLE3
Entrez ID		210
HPRD ID		00504
Ensembl ID		ENSG00000148218
Uniprot IDs		A0A024R877 A0A140VJL9 B7Z3I9 P13716 Q6ZMU0
PDB IDs		1E51 1PV8 5HMS 5HNR
Enriched GO Terms of Interacting Partners?
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