ERCC5

Description		ERCC excision repair 5, endonuclease
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GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleus Nucleoplasm Protein-containing Complex
	Molecular Function	Bubble DNA Binding RNA Polymerase II Complex Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Endonuclease Activity Endodeoxyribonuclease Activity Protein Binding Enzyme Activator Activity Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding Protein N-terminus Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Transcription-coupled Nucleotide-excision Repair Base-excision Repair, AP Site Formation Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Response To UV UV Protection Response To UV-C Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity
Pathways		Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Metabolite levels ( 23823483) Urinary calcium excretion ( 31993563)
Interacting Genes		12 interacting genes: BRCA1 BRCA2 ERCC2 ERCC6 EWSR1 GTF2H1 GTF2H4 HSPB1 NTHL1 PCNA POLR2A RAD51
Entrez ID		2073
HPRD ID		00595
Ensembl ID		ENSG00000134899
Uniprot IDs		P28715
PDB IDs		5EKF 5EKG 6TUR 6TUS 6TUW 6TUX 6VBH
Enriched GO Terms of Interacting Partners?
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