HBEGF

Description		heparin binding EGF like growth factor
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Muscle Organ Development Regulation Of Heart Contraction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Elastin Biosynthetic Process Positive Regulation Of Keratinocyte Migration Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Positive Regulation Of Wound Healing
Pathways		Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma EGFR Transactivation by Gastrin EGFR Transactivation by Gastrin Constitutive Signaling by Aberrant PI3K in Cancer Uptake and function of diphtheria toxin Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis PTK6 promotes HIF1A stabilization Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Atrial fibrillation ( 28416822) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Creatine kinase levels ( 29403010) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) White matter integrity (fractional anisotropy) ( 32358547) White matter integrity (mean diffusivity) ( 32358547)
Interacting Genes		13 interacting genes: APP BAG1 CD44 CD82 CD9 EGFR ERBB4 FBLN1 LTBP3 MMP7 NRDC REEP5 ZBTB16
Entrez ID		1839
HPRD ID		00526
Ensembl ID		ENSG00000113070
Uniprot IDs		Q99075
PDB IDs		1XDT 2M8S
Enriched GO Terms of Interacting Partners?
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