CYP1B1

Description		cytochrome P450 family 1 subfamily B member 1
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GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Aromatase Activity Estrogen 16-alpha-hydroxylase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity
	Biological Process	Angiogenesis Trabecular Meshwork Development Cellular Aromatic Compound Metabolic Process Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Cell Adhesion Steroid Metabolic Process Estrogen Metabolic Process Negative Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Toxin Metabolic Process Response To Toxic Substance Positive Regulation Of Vascular Endothelial Growth Factor Production Sterol Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Collagen Fibril Organization Negative Regulation Of Cell Migration Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Adhesion Mediated By Integrin Retinol Metabolic Process Retinal Metabolic Process Positive Regulation Of Apoptotic Process Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Membrane Lipid Catabolic Process Blood Vessel Morphogenesis Retinal Blood Vessel Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Organic Cyclic Compound Endothelial Cell-cell Adhesion Omega-hydroxylase P450 Pathway Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Endogenous sterols Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Defective CYP1B1 causes Glaucoma
Drugs		Genistein 2-Methoxyestradiol Naringenin Quercetin beta-Naphthoflavone Flavone Cannabidiol Nabiximols
Diseases
GWAS		Asthma (time to childhood onset) x early life tobacco smoke interaction ( 31379025) Basal cell carcinoma ( 31174203 33549134) Central corneal thickness ( 32528159) Cutaneous malignant melanoma ( 32341527 26237428) Frontal fibrosing alopecia ( 30850646) Keratinocyte cancer (MTAG) ( 31174203) Melanoma ( 28212542) Metabolite levels ( 23823483) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 32341527 30429480) Parkinson's disease ( 26227905)
Interacting Genes		1 interacting genes: HSPB2
Entrez ID		1545
HPRD ID		03464
Ensembl ID		ENSG00000138061
Uniprot IDs		Q16678 Q53TK1
PDB IDs		3PM0 6IQ5
Enriched GO Terms of Interacting Partners?
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