CYP1A2

Description		cytochrome P450 family 1 subfamily A member 2
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Enzyme Binding Heme Binding Demethylase Activity Caffeine Oxidase Activity Aromatase Activity Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity
	Biological Process	Steroid Catabolic Process Porphyrin-containing Compound Metabolic Process Xenobiotic Metabolic Process Cholesterol Metabolic Process Estrogen Metabolic Process Toxin Biosynthetic Process Post-embryonic Development Alkaloid Metabolic Process Regulation Of Gene Expression Monoterpenoid Metabolic Process Dibenzo-p-dioxin Metabolic Process Epoxygenase P450 Pathway Electron Transport Chain Lung Development Methylation Response To Estradiol Response To Lipopolysaccharide Monocarboxylic Acid Metabolic Process Response To Immobilization Stress Xenobiotic Catabolic Process Retinol Metabolic Process Long-chain Fatty Acid Biosynthetic Process Cellular Respiration Aflatoxin Metabolic Process Heterocycle Metabolic Process Hydrogen Peroxide Biosynthetic Process Oxidative Demethylation Cellular Response To Cadmium Ion Cellular Response To Copper Ion Omega-hydroxylase P450 Pathway
Pathways		Methylation Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Aflatoxin activation and detoxification Biosynthesis of protectins Biosynthesis of maresin-like SPMs
Drugs		Isoniazid alpha-Naphthoflavone Cannabidiol Diacerein Nabiximols
Diseases
GWAS		Bladder cancer ( 25281661) Caffeine consumption ( 21490707) Coffee consumption ( 21876539 21357676 31959922 25288136) Coffee consumption (cups per day) ( 25288136) Diastolic blood pressure ( 19430483) Lung cancer ( 28604730) Mean arterial pressure ( 27618448) Plasma clozapine levels in treatment-resistant schizophrenia ( 30922102) Red blood cell count ( 32888494 27863252) Serum albumin level ( 29403010) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		4 interacting genes: ABHD16A CYB5A CYP1A1 POR
Entrez ID		1544
HPRD ID		00489
Ensembl ID		ENSG00000140505
Uniprot IDs		P05177
PDB IDs		2HI4
Enriched GO Terms of Interacting Partners?
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