ADCY8

Description		adenylate cyclase 8
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Caveola Clathrin-coated Pit Postsynaptic Density Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Axon Dendrite Clathrin-coated Vesicle Membrane Neuronal Cell Body Membrane Plasma Membrane Raft Membrane Raft Presynaptic Active Zone Excitatory Synapse Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	Actin Binding Adenylate Cyclase Activity Calmodulin Binding ATP Binding Calcium- And Calmodulin-responsive Adenylate Cyclase Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Protein Dimerization Activity Protein Phosphatase 2A Binding
	Biological Process	CAMP Biosynthetic Process Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Memory Long-term Memory Locomotory Behavior Glucose Mediated Signaling Pathway Positive Regulation Of Synaptic Plasticity Positive Regulation Of CREB Transcription Factor Activity Activation Of Protein Kinase A Activity Intracellular Signal Transduction Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus G Protein-coupled Opioid Receptor Signaling Pathway Glucose Homeostasis Regulation Of Insulin Secretion Protein Complex Oligomerization Protein Homooligomerization Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Calcium Ion Cellular Response To Morphine Cellular Response To Glucose Stimulus Cellular Response To Glucagon Stimulus Regulation Of Cellular Response To Stress Neuroinflammatory Response Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Depression Cellular Response To Forskolin
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis
Drugs
Diseases
GWAS		Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Cerebral amyloid deposition (PET imaging) ( 30361487) Chronotype ( 26955885) Diisocyanate-induced asthma ( 25918132) HDL cholesterol levels in HIV infection ( 33109212) Lung cancer in ever smokers ( 28604730) Mild to moderate chronic kidney disease ( 31178898) Morning vs. evening chronotype ( 26955885) Post-traumatic stress disorder ( 24677629) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) Visceral adipose tissue ( 26480920)
Interacting Genes		3 interacting genes: CALM1 CALM2 PPP2CA
Entrez ID		114
HPRD ID		00051
Ensembl ID		ENSG00000155897
Uniprot IDs		A0A0K0K1K3 P40145 Q4F7X0
PDB IDs
Enriched GO Terms of Interacting Partners?
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