GPC6

Description		glypican 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Golgi Lumen Plasma Membrane Cell Surface Lysosomal Lumen Synapse Anchored Component Of Plasma Membrane Collagen-containing Extracellular Matrix Glutamatergic Synapse
	Molecular Function	Protein Binding Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway
	Biological Process	Regulation Of Signal Transduction Cell Migration Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Synaptic Membrane Adhesion Regulation Of Protein Localization To Membrane Regulation Of Presynapse Assembly
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Alzheimer's disease ( 33074286) Alzheimer's disease (cognitive decline) ( 23535033) Arterial stiffness index ( 31235810) Attention deficit hyperactivity disorder ( 18839057) Bitter alcoholic beverage consumption ( 31046077) Blood pressure (smoking interaction) ( 25189868) Breast size ( 22747683) Chronotype ( 30696823) Disc degeneration (lumbar) ( 22993228) Heel bone mineral density ( 30598549 28869591) Interleukin-6 levels ( 33517400) Mitochondrial DNA copy number (white blood cells) ( 30704525) Morning person ( 30696823) Neuroticism (age interaction) ( 20634892) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Pelvic organ prolapse ( 26545240) Refractive error ( 32231278) Renal sinus fat ( 22044751) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Tonometry ( 17903302) Visceral fat ( 22589738) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		2 interacting genes: DRD2 PTPRS
Entrez ID		10082
HPRD ID		05099
Ensembl ID		ENSG00000183098
Uniprot IDs		Q9Y625
PDB IDs
Enriched GO Terms of Interacting Partners?
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