RNF41 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	GDF11	growth differentiation factor 11
Novel	NEUROD4	neuronal differentiation 4
Novel	ORMDL2	ORMDL sphingolipid biosynthesis regulator 2	Sphingolipid de novo biosynthesis
Novel	PPP1R1A	protein phosphatase 1 regulatory inhibitor subunit 1A
Novel	SUOX	sulfite oxidase	Sulfide oxidation to sulfate	{[2-Amino-4-oxo-6,7-di(sulfanyl-ÎºS)-3,5,5a,8,9a,10-hexahydro-4H-pyrano[3,2-g]pteridin-8-yl]methyl dihydrogenato(2-) phosphate}(dioxo)sulfanylmolybdenum
Novel	TBATA	thymus, brain and testes associated
	ADRB2	adrenoceptor beta 2	Adrenoceptors G alpha (s) signalling events Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis ADORA2B mediated anti-inflammatory cytokines production	Spermine Amphetamine Betaxolol Bethanidine Isoetharine Cabergoline Metoprolol Olanzapine Atenolol Norepinephrine Timolol Phenylpropanolamine Dipivefrin Sotalol Carteolol Nortriptyline Propranolol Labetalol Bisoprolol Epinephrine Paroxetine Trimipramine Cryptenamine Orciprenaline Dobutamine Pseudoephedrine Alprenolol Ritodrine Terbutaline Bitolterol Phenoxybenzamine Salmeterol Pindolol Formoterol Salbutamol Ergoloid mesylate Isoprenaline Arbutamine Amiodarone Carvedilol Desipramine Propafenone Acebutolol Nadolol Levobunolol Metipranolol Aripiprazole Arformoterol Fenoterol Pirbuterol Bevantolol Penbutolol Ephedra sinica root Ephedrine Mephentermine Procaterol Clenbuterol Bambuterol Oxprenolol Putrescine Spermidine Celiprolol Nebivolol Indacaterol Bedoradrine NCX 950 Asenapine Droxidopa Bufuralol Protokylol (S)-carazolol Bopindolol Bupranolol Befunolol Olodaterol Vilanterol Arotinolol Doxofylline Racepinephrine Dihydroergocornine DL-Methylephedrine Etafedrine Tulobuterol Levosalbutamol Dihydroergocristine	Asthma
	AP2S1	adaptor related protein complex 2 subunit sigma 1	Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
	APP	amyloid beta precursor protein	Platelet degranulation ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Lysosome Vesicle Biogenesis Formyl peptide receptors bind formyl peptides and many other ligands TAK1 activates NFkB by phosphorylation and activation of IKKs complex The NLRP3 inflammasome Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Post-translational protein phosphorylation TRAF6 mediated NF-kB activation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Amyloid fiber formation	Deferoxamine Aluminium Zinc L-methionine (R)-S-oxide Resveratrol Tromethamine Phenserine Tetrathiomolybdate CAD106 Mito-4509 Edonerpic Dimercaprol Copper Florbetaben (18F) Florbetapir (18F) Flutemetamol (18F) Zinc acetate Aluminium phosphate Aluminum acetate Zinc chloride Zinc sulfate, unspecified form	Alzheimer's disease (AD)
	ARL6IP4	ADP ribosylation factor like GTPase 6 interacting protein 4
	ASB6	ankyrin repeat and SOCS box containing 6	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
	BIRC6	baculoviral IAP repeat containing 6
	C1orf109	chromosome 1 open reading frame 109
	ENOPH1	enolase-phosphatase 1	Methionine salvage pathway	2-OXOHEPTYLPHOSPHONIC ACID
	ERBB3	erb-b2 receptor tyrosine kinase 3		Tucatinib	Lethal congenital contractural syndrome (LCCS) Type I diabetes mellitus
	ERBB4	erb-b2 receptor tyrosine kinase 4		Afatinib Fostamatinib Brigatinib Zanubrutinib
	IRS4	insulin receptor substrate 4	IRS-related events triggered by IGF1R
	ISCA2	iron-sulfur cluster assembly 2	Mitochondrial iron-sulfur cluster biogenesis
	KDM3B	lysine demethylase 3B	HDMs demethylate histones
	LEPR	leptin receptor		Leptin Metreleptin

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