RFX3 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	AK3	adenylate kinase 3	Factors involved in megakaryocyte development and platelet production
Novel	CDK1	cyclin dependent kinase 1	MAPK3 (ERK1) activation E2F-enabled inhibition of pre-replication complex formation Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Golgi Cisternae Pericentriolar Stack Reorganization Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes APC/C:Cdc20 mediated degradation of Cyclin B Cdc20:Phospho-APC/C mediated degradation of Cyclin A Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of the APC/C Phosphorylation of Emi1 Condensation of Prophase Chromosomes MASTL Facilitates Mitotic Progression Resolution of Sister Chromatid Cohesion Condensation of Prometaphase Chromosomes Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Initiation of Nuclear Envelope (NE) Reformation Nuclear Pore Complex (NPC) Disassembly Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Depolymerisation of the Nuclear Lamina Anchoring of the basal body to the plasma membrane MAPK6/MAPK4 signaling Ovarian tumor domain proteases TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Degradation Mitotic Prophase G1/S-Specific Transcription Cyclin A/B1/B2 associated events during G2/M transition Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Transcriptional regulation by RUNX2	Indirubin-3'-monoxime Olomoucine Hymenialdisine SU9516 Alvocidib Alsterpaullone Seliciclib AT-7519 Fostamatinib
Novel	NANS	N-acetylneuraminate synthase	Sialic acid metabolism
Novel	PBRM1	polybromo 1	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Novel	SLC1A3	solute carrier family 1 member 3	Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides Defective SLC1A3 causes episodic ataxia 6 (EA6)	Glutamic acid	Episodic ataxias
Novel	TMEM9B	TMEM9 domain family member B
	BIN1	bridging integrator 1	Clathrin-mediated endocytosis		Centronuclear myopathy
	CREB1	cAMP responsive element binding protein 1	PKA-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB AKT phosphorylates targets in the nucleus CREB phosphorylation Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis NOTCH2 intracellular domain regulates transcription NCAM signaling for neurite out-growth Circadian Clock Circadian Clock CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling Constitutive Signaling by AKT1 E17K in Cancer Gastrin-CREB signalling pathway via PKC and MAPK Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels MECP2 regulates transcription of neuronal ligands MECP2 regulates transcription factors NGF-stimulated transcription NGF-stimulated transcription HCMV Early Events Transcriptional regulation of granulopoiesis Estrogen-dependent nuclear events downstream of ESR-membrane signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis	Adenosine phosphate Naloxone
	EWSR1	EWS RNA binding protein 1			Ewing's sarcoma Myxoid liposarcoma Clear cell sarcoma of soft tissue Extraskeletal myxoid chondrosarcoma
	FHL2	four and a half LIM domains 2	PPARA activates gene expression
	FHL3	four and a half LIM domains 3
	IRF6	interferon regulatory factor 6	Interferon gamma signaling Interferon alpha/beta signaling		Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate IRF6-related disorders, including: Popliteal pterygium syndrome (PPS); Van der Woude syndrome (VWS)
	MEOX2	mesenchyme homeobox 2
	PKNOX1	PBX/knotted 1 homeobox 1	Activation of anterior HOX genes in hindbrain development during early embryogenesis
	RFX1	regulatory factor X1
	RFX4	regulatory factor X4
	RFX6	regulatory factor X6	Regulation of gene expression in beta cells
	TRAF2	TNF receptor associated factor 2	Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation Defective RIPK1-mediated regulated necrosis
	TRIP6	thyroid hormone receptor interactor 6

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