PRKAR2B - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	ABCB4	ATP binding cassette subfamily B member 4	PPARA activates gene expression ABC-family proteins mediated transport Defective ABCB4 causes PFIC3, ICP3 and GBD1		Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)
Novel	CBR1	carbonyl reductase 1	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Rutin Resveratrol Heptaethylene glycol 2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400 Quercetin 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol Curcumin Curcumin sulfate
Novel	LAMB1	laminin subunit beta 1	Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MET activates PTK2 signaling Post-translational protein phosphorylation EGR2 and SOX10-mediated initiation of Schwann cell myelination	Lanoteplase
Novel	LRCH4	leucine rich repeats and calponin homology domain containing 4
Novel	MT1H	metallothionein 1H	Metallothioneins bind metals	Silver
Novel	RAP2B	RAP2B, member of RAS oncogene family	Neutrophil degranulation
Novel	RPL30	ribosomal protein L30	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Novel	TFR2	transferrin receptor 2	Transferrin endocytosis and recycling	Ferrous sulfate anhydrous Ferric derisomaltose	Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
	AKAP1	A-kinase anchoring protein 1	Mitochondrial calcium ion transport Factors involved in megakaryocyte development and platelet production
	AKAP10	A-kinase anchoring protein 10	Factors involved in megakaryocyte development and platelet production
	AKAP11	A-kinase anchoring protein 11
	AKAP14	A-kinase anchoring protein 14
	AKAP4	A-kinase anchoring protein 4
	AKAP5	A-kinase anchoring protein 5	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Trafficking of AMPA receptors ROBO receptors bind AKAP5 ROBO receptors bind AKAP5
	AKAP7	A-kinase anchoring protein 7
	AKAP9	A-kinase anchoring protein 9	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Phase 3 - rapid repolarisation Phase 2 - plateau phase Anchoring of the basal body to the plasma membrane Signaling by BRAF and RAF fusions AURKA Activation by TPX2		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
	C2orf88	chromosome 2 open reading frame 88
	CFAP91	cilia and flagella associated protein 91
	ECM1	extracellular matrix protein 1	Platelet degranulation		Lipoid proteinosis; Urbach-Wiethe disease
	GNAI3	G protein subunit alpha i3	PLC beta mediated events PLC beta mediated events Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production

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