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Novel |
APH1B |
aph-1 homolog B, gamma-secretase subunit |
- Nuclear signaling by ERBB4
- Regulated proteolysis of p75NTR
- NRIF signals cell death from the nucleus
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- EPH-ephrin mediated repulsion of cells
- NOTCH3 Activation and Transmission of Signal to the Nucleus
- NOTCH4 Activation and Transmission of Signal to the Nucleus
- Noncanonical activation of NOTCH3
- Amyloid fiber formation
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Novel |
HOXA10 |
homeobox A10 |
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Novel |
HRH1 |
histamine receptor H1 |
- Histamine receptors
- G alpha (q) signalling events
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- Citalopram
- Benzatropine
- Ziprasidone
- Clemastine
- Amitriptyline
- Olanzapine
- Cetirizine
- Terfenadine
- Buclizine
- Clozapine
- Doxylamine
- Mirtazapine
- Dexbrompheniramine
- Loxapine
- Promazine
- Triprolidine
- Prochlorperazine
- Cyproheptadine
- Loratadine
- Imipramine
- Chlorpromazine
- Haloperidol
- Nortriptyline
- Amoxapine
- Lamotrigine
- Hydroxyzine
- Cinnarizine
- Astemizole
- Trazodone
- Paroxetine
- Azatadine
- Trimipramine
- Risperidone
- Meclizine
- Carbinoxamine
- Epinastine
- Benzquinamide
- Olopatadine
- Propiomazine
- Tripelennamine
- Tolazoline
- Brompheniramine
- Methdilazine
- Ketotifen
- Maprotiline
- Fexofenadine
- Desloratadine
- Azelastine
- Dimenhydrinate
- Promethazine
- Mequitazine
- Diphenhydramine
- Emedastine
- Levocabastine
- Chlorpheniramine
- Doxepin
- Diphenylpyraline
- Desipramine
- Orphenadrine
- Escitalopram
- Cyclizine
- Quetiapine
- Bromodiphenhydramine
- Aripiprazole
- Chlorprothixene
- Alimemazine
- Paliperidone
- Methotrimeprazine
- Aceprometazine
- Phenindamine
- Pheniramine
- Zuclopenthixol
- Clofedanol
- Flunarizine
- Bepotastine
- Tesmilifene
- Iloperidone
- HY10275
- OBE101
- SO-101
- Histamine
- Epicept NP-1
- Cariprazine
- Mianserin
- Pizotifen
- Asenapine
- Ocaperidone
- Levocetirizine
- Esmirtazapine
- Mepyramine
- Betahistine
- Alcaftadine
- Antazoline
- Chloropyramine
- Dimetindene
- Isothipendyl
- Perospirone
- Chlorcyclizine
- Butriptyline
- Dosulepin
- Lorpiprazole
- Acrivastine
- Dexchlorpheniramine maleate
- Thonzylamine
- Bilastine
- Rupatadine
- Aripiprazole lauroxil
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Novel |
LRP1 |
LDL receptor related protein 1 |
- Scavenging of heme from plasma
- Retinoid metabolism and transport
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- Antihemophilic factor, human recombinant
- Tenecteplase
- Coagulation Factor IX (Recombinant)
- Lanoteplase
- Coagulation Factor IX Human
- Lonoctocog alfa
- Moroctocog alfa
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Novel |
MYO1A |
myosin IA |
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Novel |
RDH5 |
retinol dehydrogenase 5 |
- Retinoid cycle disease events
- The canonical retinoid cycle in rods (twilight vision)
- RA biosynthesis pathway
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- Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
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Novel |
SCN1A |
sodium voltage-gated channel alpha subunit 1 |
- Interaction between L1 and Ankyrins
- Phase 0 - rapid depolarisation
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- Ranolazine
- Phenytoin
- Topiramate
- Valproic acid
- Lamotrigine
- Carbamazepine
- Oxcarbazepine
- Cocaine
- Zonisamide
- Promethazine
- Phenacemide
- Phenazopyridine
- Nitrazepam
- Permethrin
- Tetrodotoxin
- Brivaracetam
- Tetracaine
- Amylocaine
- Propoxycaine
- Pramocaine
- Pentoxyverine
- Dichlorobenzyl alcohol
- Bioallethrin
- Fish oil
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- Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GEFS+); Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI)
- Familial or sporadic hemiplegic migraine
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ANK3 |
ankyrin 3 |
- Interaction between L1 and Ankyrins
- Interaction between L1 and Ankyrins
- COPI-mediated anterograde transport
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ANKRD11 |
ankyrin repeat domain 11 |
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CBX8 |
chromobox 8 |
- Oxidative Stress Induced Senescence
- SUMOylation of DNA damage response and repair proteins
- SUMOylation of transcription cofactors
- SUMOylation of chromatin organization proteins
- SUMOylation of RNA binding proteins
- SUMOylation of DNA methylation proteins
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
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CCDC187 |
coiled-coil domain containing 187 |
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CCDC33 |
coiled-coil domain containing 33 |
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CCDC57 |
coiled-coil domain containing 57 |
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CCHCR1 |
coiled-coil alpha-helical rod protein 1 |
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CDC23 |
cell division cycle 23 |
- Inactivation of APC/C via direct inhibition of the APC/C complex
- APC/C:Cdc20 mediated degradation of Cyclin B
- Autodegradation of Cdh1 by Cdh1:APC/C
- APC/C:Cdc20 mediated degradation of Securin
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
- Regulation of APC/C activators between G1/S and early anaphase
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Phosphorylation of the APC/C
- APC-Cdc20 mediated degradation of Nek2A
- Separation of Sister Chromatids
- Senescence-Associated Secretory Phenotype (SASP)
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional Regulation by VENTX
- Aberrant regulation of mitotic exit in cancer due to RB1 defects
- Antigen processing: Ubiquitination & Proteasome degradation
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CTAG1A |
cancer/testis antigen 1A |
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CTAG1B |
cancer/testis antigen 1B |
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CTNNA3 |
catenin alpha 3 |
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CWF19L2 |
CWF19 like cell cycle control factor 2 |
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DDX6 |
DEAD-box helicase 6 |
- mRNA decay by 5' to 3' exoribonuclease
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