MARK3 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	CDC42BPB	CDC42 binding protein kinase beta
Novel	HMOX2	heme oxygenase 2	Heme degradation Neutrophil degranulation Iron uptake and transport	NADH Stannsoporfin
Novel	RCOR3	REST corepressor 3
Novel	RECQL	RecQ like helicase
Novel	SLC27A4	solute carrier family 27 member 4	Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) Transport of fatty acids		Ichthyosis prematurity syndrome
	ANKRD7	ankyrin repeat domain 7
	ARHGEF2	Rho/Rac guanine nucleotide exchange factor 2	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
	ASB13	ankyrin repeat and SOCS box containing 13	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
	ATP6V0C	ATPase H+ transporting V0 subunit c	ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport	Tiludronic acid
	CDC25C	cell division cycle 25C	Polo-like kinase mediated events Activation of ATR in response to replication stress RHO GTPases activate PKNs TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Cyclin A/B1/B2 associated events during G2/M transition Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
	CHGB	chromogranin B	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
	CLASP1	cytoplasmic linker associated protein 1	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Role of ABL in ROBO-SLIT signaling Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation	Fostamatinib
	CLASP2	cytoplasmic linker associated protein 2	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Role of ABL in ROBO-SLIT signaling RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
	CPSF4	cleavage and polyadenylation specific factor 4	Transport of Mature mRNA Derived from an Intronless Transcript Inhibition of Host mRNA Processing and RNA Silencing tRNA processing in the nucleus mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
	DYNLL1	dynein light chain LC8-type 1	Activation of BIM and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
	FANCF	FA complementation group F	Fanconi Anemia Pathway		Fanconi anemia
	FBXO7	F-box protein 7	Neddylation Antigen processing: Ubiquitination & Proteasome degradation		Parkinson's disease (PD)
	HDAC7	histone deacetylase 7	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SUMOylation of DNA damage response and repair proteins Notch-HLH transcription pathway Regulation of PTEN gene transcription	Trichostatin A Belinostat Panobinostat
	KSR1	kinase suppressor of ras 1	RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
	MAP2	microtubule associated protein 2		Estramustine Paclitaxel Docetaxel

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