LARP7 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	CHRNB4	cholinergic receptor nicotinic beta 4 subunit	Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors Neutrophil degranulation	Nicotine Butabarbital Fluoxetine Dextromethorphan Ethanol Pentolinium Levacetylmethadol Epibatidine
Novel	GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2	Signaling by ERBB4 GABA receptor activation GABA receptor activation	Lorazepam Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Olanzapine Clobazam Clobazam Meprobamate Carisoprodol Eszopiclone Alprazolam Alprazolam Zolpidem Metharbital Chlordiazepoxide Chlordiazepoxide Amoxapine Adinazolam Adinazolam Lamotrigine Lamotrigine Medroxyprogesterone acetate Clorazepic acid Clorazepic acid Acamprosate Midazolam Midazolam Flurazepam Flurazepam Isoflurane Primidone Halazepam Halazepam Propofol Diazepam Diazepam Oxazepam Oxazepam Triazolam Triazolam Methoxyflurane Memantine Clonazepam Clonazepam Methyprylon Halothane Desflurane Flumazenil Flumazenil Estazolam Estazolam Sevoflurane Ginkgo biloba Glutethimide Camazepam Camazepam Delorazepam Delorazepam Flunitrazepam Flunitrazepam Ethyl loflazepate Ethyl loflazepate Cloxazolam Cloxazolam Bromazepam Bromazepam Clotiazepam Clotiazepam Fludiazepam Ketazolam Ketazolam Prazepam Prazepam Quazepam Quazepam Cinolazepam Cinolazepam Nitrazepam Nitrazepam Prasterone Taurine Adipiplon Brotizolam Brotizolam Stiripentol Etizolam Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Remimazolam Muscimol Benzodiazepine Benzodiazepine Pinazepam Pinazepam Medazepam Medazepam Loprazolam Loprazolam Doxefazepam Doxefazepam Lormetazepam Lormetazepam 5,7,2â€²-trihydroxy-6,8-dimethoxyflavone Nordazepam Nordazepam Oxazepam acetate Oxazepam acetate Cinazepam Cinazepam Bentazepam Bentazepam Mexazolam Mexazolam	Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GEFS+); Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI) Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
Novel	GAR1	GAR1 ribonucleoprotein	Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol
Novel	MCUB	mitochondrial calcium uniporter dominant negative subunit beta	Mitochondrial calcium ion transport Processing of SMDT1
Novel	OSTC	oligosaccharyltransferase complex non-catalytic subunit
Novel	PAPSS1	3'-phosphoadenosine 5'-phosphosulfate synthase 1	Transport and synthesis of PAPS Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Signaling by BRAF and RAF fusions	Adenosine-5'-diphosphate-2',3'-vanadate Adenosine 5'-phosphosulfate Glycerin
Novel	PPA2	inorganic pyrophosphatase 2	Mitochondrial tRNA aminoacylation Pyrophosphate hydrolysis
Novel	PUF60	poly(U) binding splicing factor 60	mRNA Splicing - Major Pathway
Novel	RRH	retinal pigment epithelium-derived rhodopsin homolog	G alpha (i) signalling events Opsins
Novel	SMS	spermine synthase	Metabolism of polyamines	Spermine	Snyder-Robinson syndrome
Novel	ZGRF1	zinc finger GRF-type containing 1
	APP	amyloid beta precursor protein	Platelet degranulation ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Lysosome Vesicle Biogenesis Formyl peptide receptors bind formyl peptides and many other ligands TAK1 activates NFkB by phosphorylation and activation of IKKs complex The NLRP3 inflammasome Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Post-translational protein phosphorylation TRAF6 mediated NF-kB activation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Amyloid fiber formation	Deferoxamine Aluminium Zinc L-methionine (R)-S-oxide Resveratrol Tromethamine Phenserine Tetrathiomolybdate CAD106 Mito-4509 Edonerpic Dimercaprol Copper Florbetaben (18F) Florbetapir (18F) Flutemetamol (18F) Zinc acetate Aluminium phosphate Aluminum acetate Zinc chloride Zinc sulfate, unspecified form	Alzheimer's disease (AD)
	JMJD6	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	HDMs demethylate histones
	LRRK2	leucine rich repeat kinase 2	PTK6 promotes HIF1A stabilization	Fostamatinib	Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)
	MIR1-1	microRNA 1-1
	MIR1-2	microRNA 1-2
	MIR106A	microRNA 106a
	MIR106B	microRNA 106b
	MIR107	microRNA 107
	MIR10B	microRNA 10b

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