ELOC - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	GDAP1	ganglioside induced differentiation associated protein 1	Class I peroxisomal membrane protein import
Novel	HNF4G	hepatocyte nuclear factor 4 gamma	Regulation of gene expression in beta cells Nuclear Receptor transcription pathway	Palmitic Acid
Novel	INSIG1	insulin induced gene 1	Regulation of cholesterol biosynthesis by SREBP (SREBF)
Novel	KRT8	keratin 8	Keratinization Formation of the cornified envelope	Tenecteplase Lanoteplase Copper
Novel	LY96	lymphocyte antigen 96	ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	Morphine (R)-3-hydroxytetradecanoic acid Lauric acid Myristic acid
Novel	NAA25	N-alpha-acetyltransferase 25, NatB auxiliary subunit			Type I diabetes mellitus
Novel	NFKBIA	NFKB inhibitor alpha	Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex SUMOylation of immune response proteins IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling Ub-specific processing proteases Interleukin-1 signaling TRAF6 mediated NF-kB activation	Acetylsalicylic acid Bardoxolone methyl Astaxanthin	Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect Hodgkin lymphoma
Novel	NRCAM	neuronal cell adhesion molecule	Interaction between L1 and Ankyrins NrCAM interactions Neurofascin interactions
Novel	PEX2	peroxisomal biogenesis factor 2	E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
Novel	RPL7	ribosomal protein L7	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Novel	SKAP1	src kinase associated phosphoprotein 1
Novel	UBE2W	ubiquitin conjugating enzyme E2 W	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
	ASB11	ankyrin repeat and SOCS box containing 11	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
	CBX5	chromobox 5	SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6 Factors involved in megakaryocyte development and platelet production	Copper
	CENPC	centromere protein C	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
	COMMD1	copper metabolism domain containing 1	Neddylation
	CPTP	ceramide-1-phosphate transfer protein	Glycosphingolipid metabolism
	CUL2	cullin 2	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation
	CUL3	cullin 3	Degradation of DVL Hedgehog 'on' state Regulation of RAS by GAPs Neddylation RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation
	CYP2J2	cytochrome P450 family 2 subfamily J member 2	Fatty acids Xenobiotics Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

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